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Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol

✍ Scribed by Yoon, In-Soo; Choi, Min-Koo; Kim, Jung Sun; Shim, Chang-Koo; Chung, Suk-Jae; Kim, Dae-Duk

Book ID: 119940478
Publisher: Informa plc
Year: 2010
Tongue: English
Weight: 765 KB
Volume: 41
Category: Article
ISSN: 0049-8254
DOI: 10.3109/00498254.2010.538090

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## Abstract The pharmacokinetics of L‐FMAUS after intravenous and oral administration (20, 50 and 100 mg/kg) to rats, gastrointestinal first‐pass effect of L‐FMAUS (50 mg/kg) in rats, __in vitro__ stability of L‐FMAUS, blood partition of L‐FMAUS between plasma and blood cells of rat blood, and prot