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Pharmacokinetics of amitriptyline and one of its metabolites, nortriptyline, in rats: Little contribution of considerable hepatic first-pass effect to low bioavailability of amitriptyline due to great intestinal first-pass effect

✍ Scribed by Soo K. Bae; Kyung H. Yang; Dipendra K. Aryal; Yoon G. Kim; Myung G. Lee

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 183 KB
Volume: 98
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.21511

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## Abstract The pharmacokinetics of L‐FMAUS after intravenous and oral administration (20, 50 and 100 mg/kg) to rats, gastrointestinal first‐pass effect of L‐FMAUS (50 mg/kg) in rats, __in vitro__ stability of L‐FMAUS, blood partition of L‐FMAUS between plasma and blood cells of rat blood, and prot