𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Dose-independent pharmacokinetics of ondansetron in rats: contribution of hepatic and intestinal first-pass effects to low bioavailability

✍ Scribed by Si H. Yang; Myung G. Lee


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
148 KB
Volume
29
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Hepatic and intestinal first-pass effect
✍ Soo K. Bae; Jin W. Kim; Young H. Kim; Yoon G. Kim; Sang G. Kim; Myung G. Lee πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 82 KB πŸ‘ 2 views

It was reported that the mean value of the extent of absolute oral bioavailability (F) of oltipraz at a dose of 20 mg/kg was 41.2% and only 2.68% of the oral dose was unabsorbed from the gastrointestinal tract in rats. Hence, the low F in rats could be due to considerable first-pass (gastric, intest

Pharmacokinetics and hepatic first-pass
✍ Inmaculada Soria; Dr. Cheryl L. Zimmerman πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 300 KB πŸ‘ 2 views

Studies were designed to allow an in vivo estimation of the hepatic extraction ratio and to test the hypothesis that the pharmacokinetic parameters of (-)-CBV are significantly different during anesthesia. (-)-CBV was administered as an IV bolus followed by IV infusion into either the portal (n = 3)

Dose-dependent pharmacokinetics and firs
✍ Young H. Choi; Young S. Lee; Soo H. Bae; Tae K. Kim; Bong-Y. Lee; Myung G. Lee πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 162 KB πŸ‘ 2 views

## Abstract The pharmacokinetics of mirodenafil and its two metabolites, SK3541 and SK3544, after intravenous (5, 10, 20 and 50 mg/kg) and oral (10, 20 and 50 mg/kg) administration of mirodenafil, and the first‐pass effect of mirodenafil after intravenous, oral, intraportal, intragastric and intrad

Pharmacokinetics of L-FMAUS, a new antiv
✍ Hye J. Chung; Joo H. Lee; Sung J. Woo; Hee K. Park; Chang H. Koo; Myung G. Lee πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 167 KB πŸ‘ 1 views

## Abstract The pharmacokinetics of L‐FMAUS after intravenous and oral administration (20, 50 and 100 mg/kg) to rats, gastrointestinal first‐pass effect of L‐FMAUS (50 mg/kg) in rats, __in vitro__ stability of L‐FMAUS, blood partition of L‐FMAUS between plasma and blood cells of rat blood, and prot

Pharmacokinetics of a new reversible pro
✍ Kye S. Han; Yoon G. Kim; Joong K. Yoo; Jong W. Lee; Myung G. Lee πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 175 KB πŸ‘ 1 views

The pharmacokinetics of YH1885 were evaluated after intravenous (iv) and oral administrations of the drug to rats and dogs. The reason for the low extent of bioavailability (F) of YH1885 after oral administration of the drug to rats and the absorption of the drug from various rat gastrointestinal (G