Lidocaine shows pronounced first-pass metabolism upon peroral administration in man (about 30 per cent peroral bioavailability). Since the rectal bioavailability is about 65 per cent in man it is assumed that some drug is directly absorbed into systemic circulation by-passing the liver. In rats pero
Rectal bioavailability of lidocaine in rats: Absence of significant first-pass elimination
β Scribed by A. G. de Boer; D. D. Breimer; J. Pronk; J. M. Gubbens-Stibbe
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 507 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3549
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