✦ LIBER ✦

First-pass elimination of lidocaine in the rabbit after peroral and rectal route of administration

✍ Scribed by W. A. Ritschel; H. Elconin; G. J. Alcorn; D. D. Denson

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 400 KB
Volume: 6
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510060303

No coin nor oath required. For personal study only.

✦ Synopsis

Lidocaine shows pronounced first-pass metabolism upon peroral administration in man (about 30 per cent peroral bioavailability). Since the rectal bioavailability is about 65 per cent in man it is assumed that some drug is directly absorbed into systemic circulation by-passing the liver. In rats peroral bioavailability is about 8 per cent whereas rectal bioavailability is about 100 per cent. This indicates that the rat is not a suitable model to study rectal lidocaine dosage forms. The purpose of this study was to investigate lidocaine disposition and bioavailability in rabbits after peroral and rectal administration. The peroral bioavailability in rabbits was found to be about 6 per cent and the rectal bioavailability is about 33 per cent. The results indicate that the rabbit is a suitable model for the study of systemic absorption of rectal lidocaine dosage forms.

📜 SIMILAR VOLUMES

Avoidance of hepatic first-pass effect i

Avoidance of hepatic first-pass effect in the rabbit via rectal route of administration

✍ Nahoko Kurosawa; Eiji Owada; Keiji Ito 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 2 views

To assess avoidance of hepatic first-pass effect of drugs, we undertook in situ experiments using rectal administration of lidocaine in the rabbit. We also employed in situ duodenal route to estimate first-pass metabolism across the gastrointestinal mucosa. Rabbits were administered lidocaine HCl in

First-pass elimination of salicylamide i

First-pass elimination of salicylamide in man following oral and rectal administration

✍ A. G. de Boer; D. D. Breimer; J. M. Gubbens-Stibbe; A. Bosma 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB 👁 1 views

In order t o study the avoidance of hepatic first-pass elimination following rectal administration, 500 mg of salicylamide (SAM) were given orally and rectally to man. Plasma SAM concentrations were measurable following oral administration, but following rectal administration SAM concentrations were