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First-pass elimination of salicylamide in man following oral and rectal administration

✍ Scribed by A. G. de Boer; D. D. Breimer; J. M. Gubbens-Stibbe; A. Bosma

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 474 KB
Volume: 4
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510040404

No coin nor oath required. For personal study only.

✦ Synopsis

In order t o study the avoidance of hepatic first-pass elimination following rectal administration, 500 mg of salicylamide (SAM) were given orally and rectally to man. Plasma SAM concentrations were measurable following oral administration, but following rectal administration SAM concentrations were either very low or not detectable. The mean excretion of SAM sulphate (SAMS) and SAM glucuronide (SAMG) in the urine following oral and rectal administration was 71.3 per cent and 45.6 per cent respectively. Increasing the oral and rectal dose (1500mg of SAM, solution) showed that the mean AUC values were 911 and 144pgminml-', respectively. The mean urinary excretion of SAMS plus SAMG following oral and rectal administration was 82.0 and 75.6 per cent respectively; the mean plasma elimination -half-lives were 3 I and 40min, respectively, while the mean urinary elimination half-lives were 63 and 73 min, respectively.

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