✦ LIBER ✦

Pharmacokinetics and biodistribution of genetically engineered antibodies

✍ Scribed by Surinder K Batra; Maneesh Jain; Uwe A Wittel; Subhash C Chauhan; David Colcher

Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 70 KB
Volume: 13
Category: Article
ISSN: 0958-1669
DOI: 10.1016/s0958-1669(02)00352-x

No coin nor oath required. For personal study only.

✦ Synopsis

The engineering of monoclonal antibodies has created a new generation of pharmaceuticals with the desired pharmacokinetics and biodistribution properties. For radioimmunotherapy and radioscintigraphy, optimum tumor targeting can be achieved using engineered constructs that provide high antigen affinity and specificity, effective tumor penetration, circulation properties that allow high tumor uptake with acceptable doses to the normal tissues, and fast clearance allowing low background. Recent advances have made possible the development of antibodies with these properties.

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