Radioiodination, biodistribution and pharmacokinetics of berberine in mice
β Scribed by Zejun Li; Yu Wei; Taiwei Chu
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 431 KB
- Volume
- 265
- Category
- Article
- ISSN
- 1588-2780
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## Abstract 5βBromonicotine, synthesized from nicotinic acid, was autoclaved with Na^125^I in the presence of copper sulfate and glacial acetic acid to give 5β[^125^I]iodonicotine. The radiochemical yield was 25.3%. The specific activity of the product was approximately 61 mCi/mmole. Biodistributio
Four 1251-labelled nicotine analogs were synthesized: 3-(methylpropylaminomethyl)-, 3-(diethylaminomethyl)-, 3-(isopropylaminomethy1)-, and 3-(diisopropylaminomethy1)-5-[ 1251]-iodopyridines. 5-Bromonicotinic acid was acylated with thionyl chloride and then reacted with the appropriate primary and s