✦ LIBER ✦

Pharmacokinetics and bioavailability of oral ergometrine in male volunteers

✍ Scribed by A. N. J. A. De Groot; T. B. Vree; Y. A. Hekster; M. Van Den Biggelaar-Martea; P. W. J. Van Dongen; J. Van Roosmalen

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 380 KB
Volume: 15
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510150106

No coin nor oath required. For personal study only.

✦ Synopsis

The aim of this investigation was to assess the pharmacokinetics and bioavailability of ergometrine in six human male subjects after an oral dose of 0.200 mg and after an intravenous dose of 0.075 mg of ergometrine maleate. A large variation in bioavailability of between 34% and 117% in the six volunteers was observed. The lag time was also subject dependent and ranged between 0.0073 h (0.4 min) and 0.47 h (28 min). After intravenous administration, the pharmacokinetic profile can be described by a twocompartment model. The distribution half-life t is 0.18 2 0.20 h, the elimination halflife t E O is 2.06k0.90 h, the total body clearance (CL) amounts to 35.9k 13.41 h-' and the steady-state volume ( V s s ) of distribution is 73.4+ 22-0 1. After oral administration, the pharmacokinetic profile can be described by a one-compartment model. The absorption half-life tRlabs is 0.1920.22 h, and the elimination half-life t 1 -90f 0.16 h. This study with oral ergometrine shows such a large interindividual variability in bioavailability that the oral route of administration does not seem not to be the most reliable means of accurate dosing in preventing post-partum haemorrhage.

📜 SIMILAR VOLUMES

Pharmacokinetics and safety of oral almo

Pharmacokinetics and safety of oral almotriptan in healthy male volunteers

✍ J. McEwen; M. Salva; J.M. Jansat; X. Cabarrocas 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 2 views

Single dose pharmacokinetics and bioavai

Single dose pharmacokinetics and bioavailability of nevirapine in healthy volunteers

✍ Michael J. Lamson; John P. Sabo; Thomas R. Macgregor; Joseph W. Pav; Lois Rowlan 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 2 views

The results of two randomized, single-dose, crossover bioavailability studies are presented which describe the pharmacokinetics and oral bioavailability of nevirapine, a novel nonnucleoside antiretroviral drug. In the first study 12 healthy male volunteers received nevirapine 15 mg via short-term i.

Pharmacokinetics of intravenously and or

Pharmacokinetics of intravenously and orally administered eprosartan in healthy males: absolute bioavailability and effect of food

✍ David Tenero; David Martin; Bernard Ilson; John Jushchyshyn; Steve Boike; David 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB 👁 2 views

Eighteen healthy males received a single 300 mg oral dose of eprosartan as the commercial wet granulation formulation under fasting conditions and following a high-fat breakfast and a single 20 mg intravenous (i.v.) dose. The pharmacokinetics of i.v. eprosartan (mean 9 S.D.) were characterized by a

Single-dose bioavailability of oral and

Single-dose bioavailability of oral and intramuscular thiocolchicoside in healthy volunteers

✍ P. Sandouk; M. Bouvier d'Yvoire; P. Chretien; J. P. Tillement; J. M. Scherrmann 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB 👁 2 views

A single dose of 8 mg of thiocolchicoside was administered to 12 healthy volunteers according to a Latin square design, either as tablets (reference), oral solution, or intramuscular injection. Serum thiocolchicoside concentrations showed an absorption phase followed by a biexponential decay with a

Metabolism, oral bioavailability and pha

Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats

✍ Avantika Barve; Chi Chen; Vidya Hebbar; Joseph Desiderio; Constance Lay-Lay Saw; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 155 KB 👁 1 views

## Abstract The purpose of this study was to compare the hepatic and small intestinal metabolism, and to examine bioavailability and gastro‐intestinal first‐pass effects, of kaempferol in rats. Liver and small intestinal microsomes fortified with either NADPH or UDPGA were incubated with varying co

The pharmacokinetics of oral and intrave

The pharmacokinetics of oral and intravenous prenalterol in young, healthy volunteers

✍ A. F. Clarke; D. B. Jack; M. J. Kendall; S. R. Smith 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 276 KB 👁 2 views

The pharmacokinetics of prenalterol in healthy young volunteers after i.v. and oral dosing has been studied. There is evidence of non-linearity following the i.v. dosing. Evidence of dose-dependent pharmacokinetics following i.v. dosing has been obtained. The sustained-release formulation is very ef