๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Single-dose bioavailability of oral and intramuscular thiocolchicoside in healthy volunteers

โœ Scribed by P. Sandouk; M. Bouvier d'Yvoire; P. Chretien; J. P. Tillement; J. M. Scherrmann

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
289 KB
Volume
15
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

โœฆ Synopsis

A single dose of 8 mg of thiocolchicoside was administered to 12 healthy volunteers according to a Latin square design, either as tablets (reference), oral solution, or intramuscular injection. Serum thiocolchicoside concentrations showed an absorption phase followed by a biexponential decay with a terminal half-life (f1,2@) of approximately 5 h, similar for the three formulations. The relative bioavailability of both oral formulations was approximately 25%, compared to the intramuscular formulation.

There was a trend for the oral solution to have a slightly larger AUC and C,, , as well as a slightly shorter T,, , than the tablet formulation. However, the comparison of the two oral forms did not show statistically significant differences in the pharmacokinetic parameters C,,, T,,, and AUC, suggesting that the Coltramyl@ tablets have an adequate in vivo dissolution profile.

๐Ÿ“œ SIMILAR VOLUMES

Single dose pharmacokinetics and bioavai
Single dose pharmacokinetics and bioavailability of nevirapine in healthy volunteers
โœ Michael J. Lamson; John P. Sabo; Thomas R. Macgregor; Joseph W. Pav; Lois Rowlan ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 170 KB ๐Ÿ‘ 2 views

The results of two randomized, single-dose, crossover bioavailability studies are presented which describe the pharmacokinetics and oral bioavailability of nevirapine, a novel nonnucleoside antiretroviral drug. In the first study 12 healthy male volunteers received nevirapine 15 mg via short-term i.

Single- and multiple-dose pharmacokineti
Single- and multiple-dose pharmacokinetics of oral dolasetron and its active metabolites in healthy volunteers: part 2
โœ Dan C. Dimmitt; Youn Sung Choo; Lorene A. Martin; Thangam Arumugham; William F. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 132 KB ๐Ÿ‘ 2 views

The single-and multiple-dose pharmacokinetics and dose-proportionality of oral dolasetron and its active metabolites over the therapeutic dose range was investigated in 18 healthy men. In an open-label, randomized, complete three-way crossover design, each subject received three separate doses: 50,

Single oral dose pharmacokinetics and co
Single oral dose pharmacokinetics and comparative bioavailability of danazol in humans
โœ W. D. Hooper; M. J. Eadie; R. G. Dickinson ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 335 KB ๐Ÿ‘ 2 views

## Abstract A comparative bioavailability study was conducted with two capsule formulations of danazol (200 mg) in 16 healthy adult male volunteers. Fasting subjects received single doses (400 mg) of each formulation on separate occasions 1 week apart. Blood samples were drawn at specified times up

The single dose pharmacokinetics and saf
The single dose pharmacokinetics and safety of deramciclane in healthy male volunteers
โœ Harri Kanerva; Olavi Kilkku; Esa Heinonen; Antti Helminen; Juha Rouru; Simo Tarp ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 201 KB ๐Ÿ‘ 2 views

The pharmacokinetics and tolerability of a new putative non-benzodiazepine type anxiolytic compound deramciclane was studied in two consecutive studies. An open dose-escalation design was used to study doses from 0.2 to 50 mg in 18 healthy male volunteers. In the second study doses from 50 to 150 mg