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Pharmacokinetic studies of testosterone propionate using gas chromatography/mass spectrometry/selected Ion monitoring

✍ Scribed by Yoshihiko Shinohara; Minoru Fujioka; Shigeo Baba

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
300 KB
Volume
16
Category
Article
ISSN
1076-5174

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✦ Synopsis

A sensitive and accurate method for the quantitative estimation of testosterone propionate in human plasma was developed using gas chromatogaphy/mass spectrometry/selected ion monitoring. The method employing stable isotopically labelled testosterone propionate as tracer was employed to follow the time course of plasma testosteone propionate and its active metabolite testosterone in normal men. Intramlrscularly administered (19,19,19-ZH,)testosterone propionate was readily transferred from the injection site to systemic circulation. Plasma (19,19,19-ZH,)testosterone levels were maintained above the physiological testosterone level for 48 h, while plasma levels of endogenous testosterone changed little.

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