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Determination of tryptamine in brain tissue by capillary gas chromatography mass spectrometry (selected ion monitoring)

✍ Scribed by F. Artigas; C. Suñol; J. M. Tusell; E. Martínez; E. Gelpí

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
255 KB
Volume
11
Category
Article
ISSN
1076-5174

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✦ Synopsis

The development of an analytical method for the determination of brain tryptamine using capillary gas chromatography mass spectrometry (selected ion monitoring) is presented. The method involves solvent extraction of brain homogenates and further derivatization (pentafluoropropionyl derivatives) of the dried extracts. Gas chromatographic analysis is performed using a bonded phase silica fused capillary column. Selected monitoring of mlz 289 and 292 (isotope dilution technique) allows the determination of tryptamine in adult rat brain (450f73pgg-') (XkSEM), n = 6 .

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