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Pharmacokinetic-Pharmacodynamic Relationship of Levodopa with and without Tolcapone in Patients with Parkinson’s Disease

✍ Scribed by Horst Baas, Frank Zehrden, Roland Selzer, Ralf Kohnen, Joern Loetsch, Dr med. Sebastian Harder

Book ID
119926350
Publisher
Springer International Publishing AG
Year
2001
Tongue
English
Weight
192 KB
Volume
40
Category
Article
ISSN
0312-5963

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## Abstract We explored the potential effect of catechol‐__O__‐methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from