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Pharmacokinetic model of teicoplanin in plasma, urine and blister fluid

โœ Scribed by FERRANTE, L; BOMPADRE, S; CINGOLANI, M; LEONE, L

Book ID
123343315
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
82 KB
Volume
21
Category
Article
ISSN
1043-6618

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After a single oral dose of (R,S)-ibuprofen (1200 mg) to five healthy volunteers, paired plasma and blister fluid concentrations of drug were determined by a stereospecific HPLC assay. A pharmacokinetic model that incorporated blister fluid as a separate peripheral compartment adequately characteriz