Pharmacokinetics of 8-methoxypsoralen in serum and suction blister fluid
β Scribed by Jorma Lauharanta; Timo Juvakoski; Lasse Kanerva; Allan Lassus
- Publisher
- Springer-Verlag
- Year
- 1982
- Tongue
- English
- Weight
- 233 KB
- Volume
- 273
- Category
- Article
- ISSN
- 0340-3696
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An improved fluorodensitometric assay for the determination of 8methoxypsoralen (8-MOP) in plasma is described. Because of its low limit of detection (below 1 rig/spot) this method is suitable to determine the drug in skin suction blister fluid, too. The standard deviation of the procedure is 6.4 %
After a single oral dose of (R,S)-ibuprofen (1200 mg) to five healthy volunteers, paired plasma and blister fluid concentrations of drug were determined by a stereospecific HPLC assay. A pharmacokinetic model that incorporated blister fluid as a separate peripheral compartment adequately characteriz
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