Pharmacokinetics of 8-methoxypsoralen in the dog

✍ Scribed by J. G. Monbaliu; F. M. Belpaire; R. A. Braeckman; M. G. Bogaert

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 384 KB
• Volume: 9
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bod.2510090103

✦ Synopsis

The pharmacokinetics of 8-MOP were studied in six dogs following intravenous administration of 2 mg kg-'. In most animals a bi-exponential decline of the plasma level profile was observed. The calculated pharmacokinetic parameters varied considerably between the different dogs. The mean half-lives of distribution and of elimination were 0.20 h and 2.17 h, respectively. The average total plasma clearance was 0.51 1 kg-I h-.

Following both oral and intravenous administration of doses of 1, 3, and 10 mg kg-I, non-linear kinetics were found. Non-linearity was confirmed following administration of the substance at increasing infusion rates.

Finally in four dogs, extraction by the liver was calculated by measuring 8-MOP concentration in the femoral artery and in a hepatic vein after intravenous administration of 1 mg kg-I. The extraction varied from animal to animal (18 per cent to nearly 100 per cent). Administration of an additional dose of 3 mg kg-' in two of the dogs led to a decreased extraction.