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Pharmacokinetic Analysis and Antiepileptic Activity of N-Valproyl Derivatives of GABA and Glycine

โœ Scribed by Salim Hadad; Meir Bialer

Book ID
110346876
Publisher
Springer US
Year
1995
Tongue
English
Weight
977 KB
Volume
12
Category
Article
ISSN
0724-8741

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๐Ÿ“œ SIMILAR VOLUMES

Pharmacokinetic analysis and antiepilept
Pharmacokinetic analysis and antiepileptic activity of two new isomers of N-valproyl glycinamide
โœ Salim Hadad; Meir Bialer ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 151 KB ๐Ÿ‘ 2 views

Valproyl glycinamide (TV 1901-VPGD) is a new antiepileptic drug, which is currently undergoing clinical trials. The present study explored the pharmacokinetics and pharmacodynamics (anticonvulsant activity and neurotoxicity) of two new isomers of valproyl glycinamide: valnoctyl glycinamide (VCGD) an

PHARMACOKINETIC AND PHARMACODYNAMIC ANAL
PHARMACOKINETIC AND PHARMACODYNAMIC ANALYSIS OF (E)-2-ENE VALPROYL DERIVATIVES OF GLYCINE AND VALPROYL DERIVATIVES OF NIPECOTIC ACID
โœ Meir Bialer; Bashier Kadry; Ali Abdul-Hai; Abdullah Haj-Yehia; Jeff Sterling; Ya ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 560 KB

GABA is a major inhibitory neurotransmitter in mammals, whose uptake in glial cells is inhibited by nipecotic acid. In addition to GABA, glycine is an important inhibitory neurotransmitter. Valproic acid (VPA) is one of the four established antiepileptics and (E)-2-ene valproic acid ((E)-2-ene VPA)