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Pharmacokinetics and Antiepileptic Activity of Valproyl Hydroxamic Acid Derivatives

โœ Scribed by Micha Levi; Boris Yagen; Meir Bialer

Book ID
110308607
Publisher
Springer US
Year
1997
Tongue
English
Weight
431 KB
Volume
14
Category
Article
ISSN
0724-8741

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๐Ÿ“œ SIMILAR VOLUMES

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Pharmacokinetic analysis and antiepileptic activity of two new isomers of N-valproyl glycinamide
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Valproyl glycinamide (TV 1901-VPGD) is a new antiepileptic drug, which is currently undergoing clinical trials. The present study explored the pharmacokinetics and pharmacodynamics (anticonvulsant activity and neurotoxicity) of two new isomers of valproyl glycinamide: valnoctyl glycinamide (VCGD) an

PHARMACOKINETIC AND PHARMACODYNAMIC ANAL
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GABA is a major inhibitory neurotransmitter in mammals, whose uptake in glial cells is inhibited by nipecotic acid. In addition to GABA, glycine is an important inhibitory neurotransmitter. Valproic acid (VPA) is one of the four established antiepileptics and (E)-2-ene valproic acid ((E)-2-ene VPA)