Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives
β Scribed by Sherbel Sussan; Arie Dagan; Meir Bialer
- Book ID
- 108460523
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 133 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0920-1211
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Valproyl glycinamide (TV 1901-VPGD) is a new antiepileptic drug, which is currently undergoing clinical trials. The present study explored the pharmacokinetics and pharmacodynamics (anticonvulsant activity and neurotoxicity) of two new isomers of valproyl glycinamide: valnoctyl glycinamide (VCGD) an
## Abstract The pharmacokinetics of the following two polyesteric prodrugs of valproic acid (VPA) have been investigated: 1,4βbutanediol divaiproate (BDV) and glyceryl trivalproate (GTV). In addition, the anticonvulsant activity of these compounds has been evaluated and compared to that of VPA and
GABA is a major inhibitory neurotransmitter in mammals, whose uptake in glial cells is inhibited by nipecotic acid. In addition to GABA, glycine is an important inhibitory neurotransmitter. Valproic acid (VPA) is one of the four established antiepileptics and (E)-2-ene valproic acid ((E)-2-ene VPA)