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Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice

✍ Scribed by Nina Isoherranen; Boris Yagen; Ofer Spiegelstein; Richard H Finnell; Michelle Merriweather; Jose H Woodhead; Bogdan Wlodarczyk; H Steve White; Meir Bialer

Book ID
110007837
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
225 KB
Volume
139
Category
Article
ISSN
0007-1188

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## Abstract The pharmacokinetics and efficacy of the anticonvulsant primidone (PRM) and its active metabolites, phenobarbital (PB) and phenylethylmalonamide (PEMA), were studied after single‐dose administration in mice. The half‐life of PB is twice that of PRM and PEMA. The plasma/brain ratios prov