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Periampullary Adenomas and Adenocarcinomas in Familial Adenomatous Polyposis: Cumulative Risks and APC Gene Mutations

✍ Scribed by Jan Björk; Helena Åkerbrant; Lennart Iselius; Annika Bergman; Yvonne Engwall; Jan Wahlström; Tommy Martinsson; Margareta Nordling; Rolf Hultcrantz

Book ID
119756388
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
199 KB
Volume
121
Category
Article
ISSN
0016-5085

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Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua