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Peptide synthesis ‘in water’ by a solution-phase method using water-dispersible nanoparticle Boc-amino acid

✍ Scribed by Keiko Hojo; Hideki Ichikawa; Mare Onishi; Yoshinobu Fukumori; Koichi Kawasaki

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
299 KB
Volume
17
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

Regulatory pressure has compelled the chemical manufacturing industry to reduce the use of organic solvents in synthetic chemistry, and there is currently a strong focus on replacing these solvents with water. Here, we describe an efficient in‐water solution‐phase peptide synthesis method using Boc‐amino acids. It is based on a coupling reaction utilizing suspended water‐dispersible nanoparticle reactants. Using this method, peptides were obtained in good yield and with high purity. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.

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