Peptide synthesis by a combination of solid-phase and solution methods IV minimum-racemization coupling of nα-9-fluorenylmethyloxycarbonyl amino acids to alkoxy benzyl alcohol type resins

✍ Scribed by M. Mergler; R. Nyfeler; J. Gosteli; R. Tanner

• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 175 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)70666-6

✦ Synopsis

The cesium salts of N -9-fluorenylmethyloxycarbonyl (Fmoc) amino acids couple smoothly to new chloro derivatives of alkoxy benryl alcohol resins. While high loading is attained under mild reaction conditions racemization can be suppressed even with Cys and His derivatives.