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Peptide Nucleic Acids (PNAs) and Their Analogues: Synthesis and Applications

✍ Scribed by Roberto Corradini; Stefano Sforza; Tullia Tedeschi; Rosangela Marchelli


Publisher
John Wiley and Sons
Year
2004
Weight
50 KB
Volume
35
Category
Article
ISSN
0931-7597

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Peptide Nucleic Acids (PNAs) are DNA mimics in which the chiral monomer inserted in the middle of the strand is able to induce a strong preference in the helix handedness of a deoxyribose phosphate backbone has been replaced by a pseudo-peptide skeleton composed of N-(2-aminoethyl)-PNA-PNA duplex. T