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Synthesis, Properties and Functions of Peptide Nucleic Acids (PNA) and Their Derivatives

โœ Scribed by Reiko Iwase; Akira Murakami


Publisher
John Wiley and Sons
Year
2003
Weight
57 KB
Volume
34
Category
Article
ISSN
0931-7597

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Solid-phase synthesis of peptide nucleic
โœ Gudrun Aldrian-Herrada; Alain Rabiรฉ; Reinhold Wintersteiger; Jean Brugidou ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 227 KB ๐Ÿ‘ 2 views

A new simple solid-phase method has been developed for synthesizing Boc-protected peptide nucleic acid (PNA) monomers. An immobilized backbone 3 was built on Expansin ยฎ resin using an ester disulphide handle: 2-hydroxypropyl-dithio-2%-isobutyric acid (HPDI). The base acetic acids of thymine 5, Z-cyt