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Peptide Nucleic Acids(PNAs)—Unusual Properties of Nonionic Oligonucleotide Analogues

✍ Scribed by Dr. Chris Meier; Prof. Dr. Joachim W. Engels

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
369 KB
Volume
31
Category
Article
ISSN
0044-8249

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The synthesis of two novel PNA nucleobases derived from 1,8-naphthyridin-2(1H)-one (bT) and benzo[b]-1,8-naphthyridin-2(1H)-one (tT) are reported, together with their incorporation into oligomers of PNA and evaluation as substitutes for thymine. Compound bT is shown to be an effective mimic of the n