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Pentazocine-like discriminative stimulus effects of morphine are blocked by the dopamine D-1 antagonist SCH23390, but not by the dopamine D-2 antagonist sulpiride

โœ Scribed by Makoto Ukai; Eiko Hiraiwa; Tsutomu Kameyama

Book ID
115802033
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
261 KB
Volume
541
Category
Article
ISSN
0006-8993

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Blockade of the discriminative stimulus
Blockade of the discriminative stimulus effects of cocaine in rhesus monkeys with the D1dopamine antagonist SCH 23390
โœ Mark S. Kleven; Elizabeth W. Anthony; Leon I. Goldberg; William L. Woolverton ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 317 KB

To investigate the role of D, dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 rag/ kg, IM) from saline. Administration of various doses of cocaine resulted