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Blockade of the discriminative stimulus effects of cocaine in rhesus monkeys with the D1dopamine antagonist SCH 23390

✍ Scribed by Mark S. Kleven; Elizabeth W. Anthony; Leon I. Goldberg; William L. Woolverton

Publisher: Springer
Year: 1988
Tongue: English
Weight: 317 KB
Volume: 95
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00181961

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✦ Synopsis

To investigate the role of D, dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 rag/ kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related increase in the percentage of responses that occurred on the drug-appropriate lever. Administration of the D~ antagonist SCH 23390 20 min before cocaine reduced drug-appropriate responding from 100% to 0% in all subjects and increased by 4-8-fold the cocaine dose necessary to induce drug-appropriate responding. A mutual antagonism of the rate-decreasing effects of cocaine and SCH 23390 was also observed. These findings suggest that D t receptors play a significant role in the discriminative stimulus and rate-decreasing effects of cocaine.

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