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Attenuation of the locomotor-sensitizing effects of the D2 dopamine agonist bromocriptine by either the D1 antagonist SCH 23390 or the D2 antagonist raclopride

✍ Scribed by Roy A. Wise; William A. Carlezon Jr.

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
525 KB
Volume
17
Category
Article
ISSN
0887-4476

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✦ Synopsis

Injections of the selective D, dopamine agonist bromocriptine (5.0 mg/ kg, IP) produced progressively stronger locomotion over 10 days of repeated testing. Concurrent treatment with either the D, antagonist SCH 23390 (0.01 or 0.1 mg/kg, IP) or the D, antagonist raclopride (0.1 or 1.0 mg/kg, IP) suppressed bromocriptine-induced locomotion on treatment days and attenuated or blocked the progressive increases in locomotion that accompanied repeated injections of bromocriptine alone. The fact that D, and D, antagonists each block the acute actions of bromocriptine and attenuate the development of bromocriptine sensitization is suggested to imply a striatal rather than a ventral tegmental mechanism for the sensitization produced by repeated treatments with direct dopamine agonists. o 1994 Wiley-Liss, Inc.

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