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PEGylation of a Factor VIII–Phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice

✍ Scribed by Aaron Peng; Matthew P. Kosloski; Genki Nakamura; Hong Ding; Sathy V. Balu-Iyer


Book ID
118728976
Publisher
American Association of Pharmaceutical Scientists
Year
2011
Tongue
English
Weight
233 KB
Volume
14
Category
Article
ISSN
1550-7416

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Recombinant human factor VIII (rFVIII), a multidomain glycoprotein is used in replacement therapy for treatment of hemophilia A. Unfortunately, 15%-30% of the treated patients develop inhibitory antibodies. The pathogenesis of antibody development is not completely understood. The presence of aggreg