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Safety and pharmacokinetics of a recombinant factor VIII with pegylated liposomes in severe hemophilia A

✍ Scribed by J. S. POWELL; D. J. NUGENT; J. A. HARRISON; A. SONI; A. LUK; H. STASS; E. GORINA


Book ID
109152436
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
227 KB
Volume
6
Category
Article
ISSN
1538-7933

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Factor VIII (FVIII) is a multidomain protein that is deficient in hemophilia A, a clinically important bleeding disorder. Replacement therapy using recombinant human FVIII (rFVIII) is the main therapy. However, approximately 15-30% of patients develop inhibitory antibodies that neutralize rFVIII act