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Native-like aggregates of factor VIII are immunogenic in von Willebrand factor deficient and hemophilia a mice

✍ Scribed by Dipak S. Pisal; Matthew P. Kosloski; C. Russell Middaugh; Richard B. Bankert; Sathy V. Balu-iyer


Book ID
112134493
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
357 KB
Volume
101
Category
Article
ISSN
0022-3549

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Influence of aggregation on immunogenici
✍ Vivek S. Purohit; C. Russell Middaugh; Sathyamangalam V. Balasubramanian πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 221 KB

Recombinant human factor VIII (rFVIII), a multidomain glycoprotein is used in replacement therapy for treatment of hemophilia A. Unfortunately, 15%-30% of the treated patients develop inhibitory antibodies. The pathogenesis of antibody development is not completely understood. The presence of aggreg