## Abstract ## Background Most alveolar rhabdomyosarcomas (ARMS) have chromosome translocations and resultant gene fusion products. The more common translocation fuses the PAX3 and FKHR genes; patients who have PAX3‐FKHR‐positive ARMS have reduced event‐free survival compared to patients with ARMS
PAX3-FKHR AND PAX7-FKHR FUSION GENES IMPACT OUTCOME OF ALVEOLAR RHABDOMYOSARCOMA IN CHILDREN
✍ Scribed by Kazanowska, Bernarda; Reich, Adam; Stegmaier, Sabine; Békássy, Albert N.; Leuschner, Ivo; Chybicka, Alicja; Koscielniak, Ewa
- Book ID
- 120340943
- Publisher
- Informa plc
- Year
- 2007
- Tongue
- English
- Weight
- 661 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1551-3815
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## Abstract __PAX3__ and __PAX7__ encode transcription factors implicated in the pathogenesis of rhabdomyosarcoma (RMS), including alveolar RMS in which chromosomal translocations generate __PAX3‐FKHR__ and __PAX7‐FKHR__ fusions. Previous studies of wild‐type PAX3 and PAX7 identified alternative sp
Alveolar rhabdomyosarcomas frequently exhibit specific translocations, resulting in the fusion of the FKHR gene at 13q 14 with either the PAX3 or PAX7 gene at 2q35 and I p36, respectively. Comparative genomic hybridization revealed amplification at 13q14 and lp36, suggesting amplification of the PAX