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Identification of Target Genes Regulated by PAX3 and PAX3–FKHR in Embryogenesis and Alveolar Rhabdomyosarcoma

✍ Scribed by Thomas D Barber; Melisa C Barber; Oana Tomescu; Frederic G Barr; Steve Ruben; Thomas B Friedman

Book ID
115615560
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
161 KB
Volume
79
Category
Article
ISSN
0888-7543

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## Abstract ## Background Most alveolar rhabdomyosarcomas (ARMS) have chromosome translocations and resultant gene fusion products. The more common translocation fuses the PAX3 and FKHR genes; patients who have PAX3‐FKHR‐positive ARMS have reduced event‐free survival compared to patients with ARMS