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Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma

✍ Scribed by Ken Kikuchi; Kunihiko Tsuchiya; Osamu Otabe; Takahiro Gotoh; Shinichi Tamura; Yoshiki Katsumi; Shigeki Yagyu; Satoko Tsubai-Shimizu; Mitsuru Miyachi; Tomoko Iehara; Hajime Hosoi

Book ID: 116295961
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 827 KB
Volume: 365
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.11.017

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## Abstract ## Background Most alveolar rhabdomyosarcomas (ARMS) have chromosome translocations and resultant gene fusion products. The more common translocation fuses the PAX3 and FKHR genes; patients who have PAX3‐FKHR‐positive ARMS have reduced event‐free survival compared to patients with ARMS