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Lack of effective T-lymphocyte response to the PAX3/FKHR translocation area in alveolar rhabdomyosarcoma

โœ Scribed by David A. Rodeberg; Rebecca A. Nuss; Carrie J. Heppelmann; Esteban Celis

Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
327 KB
Volume
54
Category
Article
ISSN
0340-7004

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Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization
โœ Jaclyn A. Biegel; Lynn M. Nycum; Virginia Valentine; Frederic G. Barr; David N. ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 600 KB

Cytogenetic studies of the pediatric solid tumor alveolar rhabdomyosarcoma have demonstrated the presence of a consistent chromosomal translocation, t(2 I3)(q35;q 14). We recently identified PAX3 and FKHR as the genes on chromosomes 2 and I 3, respectively, that are juxtaposed by this translocation.