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Novel formation and amplification of the PAX7-FKHR fusion gene in a case of alveolar rhabdomyosarcoma

✍ Scribed by S. Weber-Hall; A. McManus; J. Anderson; T. Nojima; S. Abe; K. Pritchard-Jones; J. Shipley

Book ID
114136560
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
78 KB
Volume
91
Category
Article
ISSN
0165-4608

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Novel formation and amplification of the
Novel formation and amplification of the PAX7-FKHR fusion gene in a case of alveolar rhabdomyosarcoma
✍ Stephen Weber-Hall; Aidan McManus; John Anderson; Takayuki Nojima; Syuiti Abe; K πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 844 KB

Alveolar rhabdomyosarcomas frequently exhibit specific translocations, resulting in the fusion of the FKHR gene at 13q 14 with either the PAX3 or PAX7 gene at 2q35 and I p36, respectively. Comparative genomic hybridization revealed amplification at 13q14 and lp36, suggesting amplification of the PAX

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## Abstract ## Background Most alveolar rhabdomyosarcomas (ARMS) have chromosome translocations and resultant gene fusion products. The more common translocation fuses the PAX3 and FKHR genes; patients who have PAX3‐FKHR‐positive ARMS have reduced event‐free survival compared to patients with ARMS