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Investigation of PAX3/7-FKHR fusion genes and IGF2 gene expression in rhabdomyosarcoma tumors

✍ Scribed by Robson Ramos de Souza; Indhira Dias Oliveira; Eliana Maria Monteiro Caran; Maria Teresa de Seixas Alves; Simone Abib; Silvia Regina Caminada Toledo

Book ID: 119241881
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 262 KB
Volume: 22
Category: Article
ISSN: 1096-6374
DOI: 10.1016/j.ghir.2012.07.003

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Alveolar rhabdomyosarcomas frequently exhibit specific translocations, resulting in the fusion of the FKHR gene at 13q 14 with either the PAX3 or PAX7 gene at 2q35 and I p36, respectively. Comparative genomic hybridization revealed amplification at 13q14 and lp36, suggesting amplification of the PAX