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Therapeutic cytodifferentiation in alveolar rhabdomyosarcoma without genetic change of the PAX3-FKHR chimeric fusion gene: a case study

✍ Scribed by Michiyuki Hakozaki, Hiroshi Hojo, Takahiro Tajino, Hitoshi Yamada…


Book ID
120730596
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
833 KB
Volume
26
Category
Article
ISSN
0914-7470

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✍ Stephen Weber-Hall; Aidan McManus; John Anderson; Takayuki Nojima; Syuiti Abe; K 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 844 KB

Alveolar rhabdomyosarcomas frequently exhibit specific translocations, resulting in the fusion of the FKHR gene at 13q 14 with either the PAX3 or PAX7 gene at 2q35 and I p36, respectively. Comparative genomic hybridization revealed amplification at 13q14 and lp36, suggesting amplification of the PAX