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Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case

โœ Scribed by Anthony Gordon; Aidan McManus; John Anderson; Cyril Fisher; Syuiti Abe; Takayuki Nojima; Kathy Pritchard-Jones; Janet Shipley


Book ID
114135437
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
136 KB
Volume
140
Category
Article
ISSN
0165-4608

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โœ Stephen Weber-Hall; Aidan McManus; John Anderson; Takayuki Nojima; Syuiti Abe; K ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 844 KB

Alveolar rhabdomyosarcomas frequently exhibit specific translocations, resulting in the fusion of the FKHR gene at 13q 14 with either the PAX3 or PAX7 gene at 2q35 and I p36, respectively. Comparative genomic hybridization revealed amplification at 13q14 and lp36, suggesting amplification of the PAX