Pathways for self-tolerance and the treatment of autoimmune diseases
β Scribed by Christopher C Goodnow
- Book ID
- 117277498
- Publisher
- The Lancet
- Year
- 2001
- Tongue
- English
- Weight
- 117 KB
- Volume
- 357
- Category
- Article
- ISSN
- 0140-6736
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Autoimmune diseases are characterized by the loss of tolerance toward selfβantigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a nonβspec
ral tolerance describes the observation that a state of hyporesponsiveness follows immunization with a previously fed protein. It was first described in 1911 when Wells fed hen egg proteins to guinea-pigs and found them resistant to anaphylaxis when challengedL In 1946, Chase fed guinea-pigs the con
Oral tolerance is the phenomenon of systemic, antigen specific, immunological hyporesponsiveness that results from oral administration of a protein. The mechanism by which tolerance is generated depends on the amount of antigen administered; low doses favor induction of regulatory T cells while high