## Abstract Autoimmune diseases are characterized by the loss of tolerance toward selfโantigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a nonโspec
Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease
โ Scribed by Miller, Stephen D.; Turley, Danielle M.; Podojil, Joseph R.
- Book ID
- 109955751
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 972 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri2153
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Based on the analyses of approximately 1,000 infants with CLD, this condition was classified into 7 types according to the preceding illnesses and the chest X-ray appearance. The profile of inflammatory enzymes, cytokines and chemical mediators supported the relevance of the classification. Since di
## Abstract In this review, we discuss Tโcell activation, etiology, and the current therapies of autoimmune diseases (i.e., MS, T1D, and RA). Tโcells are activated upon interaction with antigenโpresenting cells (APC) followed by a โbull's eyeโโlike formation of the immunological synapse (IS) at the