Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations
✍ Scribed by Prud'homme, Gérald J
- Book ID
- 109886193
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 291 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0023-6837
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Skin fibrotic disorders are understood to develop under the influence of some growth factors, such as transforming growth factor-beta (TGF-), basic fibroblast growth factor (bFGF), or connective tissue growth factor (CTGF). To establish an appropriate animal model of skin fibrosis by exogenous appl
Transforming growth factor-b (TGF-b) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-b can either promote or suppress inflamm