Transforming growth factor-β signaling i
✍
Suvi-Katri Leivonen; Veli-Matti Kähäri
📂
Article
📅
2007
🏛
John Wiley and Sons
🌐
French
⚖ 229 KB
## Abstract Transforming growth factor‐β (TGF‐β) family members are polypeptides with dual tumor suppressive and oncogenic effects. They signal through serine/threonine kinase receptor complexes, which phosphorylate cytoplasmic mediators, the Smads. Upon phosphorylation, Smads translocate to the nu