𝔖 Bobbio Scriptorium
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Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer

✍ Scribed by Linda A. Feagins

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
263 KB
Volume
16
Category
Article
ISSN
1078-0998

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✦ Synopsis

Transforming growth factor-b (TGF-b) plays a central role in a wide array of cellular functions including control of cell growth and differentiation, embryonic development, wound healing, angiogenesis, and immune regulation. In the gastrointestinal tract, TGF-b can either promote or suppress inflammation and cancer formation. This report reviews recent data on the role of TGF-b in the pathogenesis of inflammatory bowel disease and how TGF-b might contribute to the cancer risk associated with chronic inflammation of the gut.

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