Reciprocal balance of hepatocyte growth factor and transforming growth factor-β1 in renal fibrosis in mice
✍ Scribed by Mizuno, Shinya; Matsumoto, Kunio; Kurosawa, Tsutomu; Mizuno-Horikawa, Yoko; Nakamura, Toshikazu
- Book ID
- 110052364
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 862 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0085-2538
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After a partial hepatectomy, TGF-a mRNA has been shown of chronic liver disease; CH, chronic hepatitis; LC, liver cirrhosis; LI, labeling index; RTto increase in hepatocytes at the time of DNA synthesis con-PCR, reverse-transcriptase polymerase chain reaction; cDNA, complementary DNA.
Hepatocyte growth factor, a potent hepatocyte mitogen in vitro, appears to trigger hepatocyte regeneration after partial hepatectomy and after acute liver cell netcrosis. Transforming growth factor-a and transforming growth factor+, may also be involved in the control of liver regeneration. In this