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Part I: Hodgkin's lymphoma—molecular biology of Hodgkin and Reed-Sternberg cells

✍ Scribed by Roman K Thomas; Daniel Re; Jürgen Wolf; Volker Diehl


Book ID
117783077
Publisher
The Lancet
Year
2004
Tongue
English
Weight
554 KB
Volume
5
Category
Article
ISSN
1470-2045

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Molecular biology of Hodgkin's and Reed/
✍ Andreas Bräuninger; Roland Schmitz; Dörte Bechtel; Christoph Renné; Martin-Leo H 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 203 KB

## Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's lymphoma (HL), represent transformed B cells in nearly all cases. The detection of destructive somatic mutations in the rearranged immunoglobulin (Ig) genes of HRS cells in classical HL indicated that they