Aberrant expression of cell cycle regulators in Hodgkin and Reed–Sternberg cells of classical Hodgkin's lymphoma
✍ Scribed by Tzankov, Alexandar; Zimpfer, Annette; Went, Philip; Maurer, Robert; Pileri, Stefano A; Geley, Stephan; Dirnhofer, Stephan
- Book ID
- 109888120
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 197 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0893-3952
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## Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's lymphoma (HL), represent transformed B cells in nearly all cases. The detection of destructive somatic mutations in the rearranged immunoglobulin (Ig) genes of HRS cells in classical HL indicated that they
## Abstract Hodgkin and Reed‐Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) show genotypic features of germinal centre‐derived B‐cells in most cases. Nevertheless, these cells typically lack expression of B‐cell antigens. Previous studies have suggested that plasma cell differentiation m