Targetable oncogenic pathways in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
✍ Scribed by A. Tzankov
- Book ID
- 107636623
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 204 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1865-5041
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## Abstract Hodgkin and Reed‐Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) show genotypic features of germinal centre‐derived B‐cells in most cases. Nevertheless, these cells typically lack expression of B‐cell antigens. Previous studies have suggested that plasma cell differentiation m
## Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's lymphoma (HL), represent transformed B cells in nearly all cases. The detection of destructive somatic mutations in the rearranged immunoglobulin (Ig) genes of HRS cells in classical HL indicated that they
## Abstract There has been substantial advances in our understanding of the nature of the Hodgkin/Reed–Sternberg (H/RS) cell in recent years. There is now compelling evidence that the H/RS cells in the vast majority of cases of classical Hodgkin's disease (CHD) are derived from the B‐cell lineage a
In eight cases of Hodgkin's disease of various types, Ig was found within approximately one-third of the RS and HD cells. The Ig within each RS and HD cell consisted of gamma heavy chains and both k and lambda light chains. The most probable origin of the Ig would appear to be uptake of IgG-containi