## Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's lymphoma (HL), represent transformed B cells in nearly all cases. The detection of destructive somatic mutations in the rearranged immunoglobulin (Ig) genes of HRS cells in classical HL indicated that they
The Molecular Basis for the Generation of Hodgkin and Reed-Sternberg Cells in Hodgkin’s Lymphoma
✍ Scribed by Im-Soon Lee; Seok Hyung Kim; Hyung Geun Song; Seong Hoe Park
- Publisher
- Carden Jennings Publishing
- Year
- 2003
- Tongue
- English
- Weight
- 96 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0925-5710
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## Abstract There has been substantial advances in our understanding of the nature of the Hodgkin/Reed–Sternberg (H/RS) cell in recent years. There is now compelling evidence that the H/RS cells in the vast majority of cases of classical Hodgkin's disease (CHD) are derived from the B‐cell lineage a
## Abstract Hodgkin and Reed‐Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) show genotypic features of germinal centre‐derived B‐cells in most cases. Nevertheless, these cells typically lack expression of B‐cell antigens. Previous studies have suggested that plasma cell differentiation m
There is accumulating evidence to suggest that Hodgkin and Reed-Sternberg (HRS) cells represent the malignant cell population in Hodgkin's disease (HD). A recent report that HD tissue is in most instances devoid of telomerase activity was therefore unexpected. Since telomerase activity was determine
## Abstract In the search for viruses in Hodgkin lymphoma (HL), it was reported that the measles virus (MV) can be detected in the Hodgkin‐Reed/Sternberg (HRS) cells of a large fraction of cases from Israel by immunohistochemistry or __in situ__ hybridisation, suggesting a potential role of this vi